SIRT1/NF-κB pathway on neuronal apoptosis
Corresponding Writer(s) : YiShun Shao
wzz1602@126.com
Mobile and Molecular Biology,
Vol. 68 No. 5: Subject 5
Summary
Current research have proven that neuronal apoptosis is among the essential mechanisms resulting in cerebral ischemic harm. SIRT1/NF-κB is a service of protein models within the physique, participates within the synthesis of DNA, RNA and essential neurotransmitters within the mind, and is a crucial nutrient crucial to keep up the traditional progress and improvement of the nervous system and the traditional operate of cells. This text goals to review the impact of the SIRT1/NF-κB pathway on neuronal apoptosis in rats with ischemic stroke. Rats had been divided into sham operation group, mannequin group, SIRT1/NF-κB group, every group was given intragastric administration at completely different doses 3 days earlier than the operation and after the operation, and mind tissue was taken at 24, 48, 72, 96 h after operation HE staining, TTC staining and dynamic modifications of SIRT1/NF-κB expression had been measured. The outcomes of the experiment confirmed that the results of Nao Xintong was low, and the SIRT1/NF-κB group might cut back the quantity of cerebral infarction in rats (P <0.05), and cut back the expression of SIRT1/NF-κB optimistic cells. The experimental outcomes present that Naoxintong SIRT1/NF-κB has a protecting impact on neuronal apoptosis after focal cerebral ischemia-reperfusion in rats.
Key phrases
Neuronal Apoptosis
Cerebral Ischemic Damage
SIRT1/NF-κB
Protecting Impact
Gao, H. ., Yang, L. ., & Shao, Y. . (2022). SIRT1 / NF-κB pathway on neuronal apoptosis in rats with ischemic stroke: SIRT1/NF-κB pathway on neuronal apoptosis. Mobile and Molecular Biology, 68(5), 77–82. https://doi.org/10.14715/cmb/2022.68.5.10
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